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Updated: Jan 10, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

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SP1-SuperEnhancer-SPHK1轴在TNBC中调解了尼拉帕里布抗性

Yu-Xia Yuan1,2, Rui-Jia Chen1,2, Gui-Hui Tu1,2

  • 1Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350000, China.

Pharmaceuticals (Basel, Switzerland)
|November 27, 2025
PubMed
概括

三重阴性乳腺癌中尼拉巴里布耐药性是由SP1-超级增强剂-SPHK1通路驱动的. 天然化合物Echinatin通过抑制SP1来逆转这种抵抗,增强Niraparib.

关键词:
SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1这就是SPHK1的原因.尼拉帕里布里布里布.脂体的新陈代谢过程这些超级增强剂是超级增强剂.

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