通过定制的脂质体载体提取橄叶提取物的价值化:物理化学特征,抗氧化能力和稳定性的比较分析
Jovan Baljak1,2, Dragana Dekanski3, Andrea Pirković3
1Center for Forensic Medicine, Toxicology and Molecular Genetics, Clinical Center of Vojvodina, 21000 Novi Sad, Serbia.
Pharmaceuticals (Basel, Switzerland)
|November 27, 2025
概括
脂脂质体有效封装橄叶提取物多,增强稳定性和生物可用性. 不同的脂质体配方选择性地捕获各种化合物,PG90显示出优越的长期稳定性和受控释放,以改善输送.
科学领域:
- 食品科学与技术 食品科学与技术
- 制药科学 制药科学
- 生物化学 生物化学
背景情况:
- 橄叶提取物是橄油生产的副产品,富含生物活性.
- 低溶解度和稳定性限制了橄叶的应用.
- 需要封装策略来提高生物可用性和稳定性.
研究的目的:
- 为了比较三种基于脂的脂质体系统 (AL,PG90,PH90) 用于封装乙醇橄叶提取物.
- 评估脂成分对封装效率,稳定性和释放动态的影响.
- 评估量身定制的脂质体的潜力,以提高橄叶多的输送.
主要方法:
- 用橄叶提取物加载的三个脂质体配方 (AL,PG90,PH90) 的制备和表征.
- 物理化学分析,包括封装效率 (EE),抗氧化活性,形态学和释放动力学.
- 在模拟生理条件下60天的稳定性研究.
- 先进的分析技术:HPLC,GC-MS,FT-IR,TEM,以及NTA. 这些分析技术包括:
主要成果:
- 欧蛋白的高EE (高达76.18%) 和极性 (AL,PG90) 或非极性 (PH90) 化合物的选择性封装.
- 在负载的脂质体中保持高的抗氧化活性.
- 通过减少颗粒大小和增强电泳性移动性,提高了合体稳定性.
- PG90脂质体表现出最稳定的移动性特征和长时间的多释放.
结论:
- 脂成分对于确定封装的选择性,稳定性和释放特性至关重要.
- 量身定制的脂质体系统显著提高了橄叶多的稳定性和输送.
- 这些发现支持在生物活性输送平台中使用脂质体,以改善健康益处.
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