乳酸菌兰姆诺索斯 (Lactobacillus rhamnosus) GG的使用与刺激维生素D/VDR通路和粘膜微生物群调节有关:性结肠炎患者的试点研究
相关实验视频
Updated: Jan 10, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Cristiano Pagnini1, Manuele Gori2, Maria Carla Di Paolo1
1Gastroenterology and Digestive Endoscopy Department, S. Giovanni Addolorata Hospital, 00184 Rome, Italy.
这项研究表明, *Lactobacillus rhamnosus* GG (LGG) 益生菌补充剂增加了性结肠炎患者的结肠中维生素D受体 (VDR) 表达. 这表明LGG可以通过影响VDR通路和肠道微生物群来帮助管理性结肠炎.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 维生素D/维生素D受体 (VDR) 途径在炎症性肠病 (IBD) 中被探索用于免疫调节.
- *Lactobacillus rhamnosus* GG (LGG) 在性结肠炎 (UC) 中表现有前途,但它对人类的VDR通路的影响尚不清楚.
研究的目的:
- 调查LGG是否可以刺激UC患者的维生素D/VDR通路.
- 为了确定LGG是否调节粘膜粘附微生物群组成.
主要方法:
- 从LGGinUC试验中分析了13名轻度至中度UC患者,他们接受了四周的LGG单疗法.
- 在使用RT-qPCR和免疫组织化学的结肠活检中评估VDR表达 (mRNA和蛋白质).
- 通过DNA提取和下一代测序 (NGS) 评估粘膜粘附的微生物群组成.
主要成果:
- 服用LGG显著增加了VDR mRNA表达 (p <0.05) 和结肠粘膜中的蛋白质水平.
- 微生物群分析表明,α-多样性减少,主要是由于共生细菌减少.
- 微生物群的β多样性基本保持不变.
结论:
- 这是第一个人类研究表明,益生菌补充剂调高了结肠粘膜中的VDR表达.
- 通过刺激VDR通路,影响粘膜免疫和微生物群,LGG可能有利于UC患者.
- 需要对更大的队列和更长时间的研究进行进一步的研究,以证实研究结果和治疗潜力.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

