便微生物群移植在耐药性免疫介导性结肠炎:病例系列和文献综述
Marin Golčić1,2, Laura Radoš1, Iva Skočilić1,2
1Clinic for Tumors, Clinical Hospital Centre Rijeka, 51000 Rijeka, Croatia.
Pharmaceuticals (Basel, Switzerland)
|November 27, 2025
概括
便微生物种移植 (FMT) 为严重免疫媒介性结肠炎 (IMC) 提供了一个有前途的新疗法,该疾病对标准疗法没有反应. 这项研究表明,FMT可以安全有效地解决癌症患者的耐火性IMC.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症治疗方法,但可以引起免疫介导性结肠炎 (IMC).
- 像皮质类固醇,infliximab或vedolizumab这样的标准治疗方法对于严重的IMC并不总是有效.
- 耐火性IMC需要探索替代疗法,例如便微生物群移植 (FMT).
研究的目的:
- 评估便微生物群移植 (FMT) 作为耐性免疫介导性结肠炎 (IMC) 的救援疗法的安全性和有效性.
主要方法:
- 两名患有III级IMC的患者,不耐皮质类固醇和因弗力西马布治疗,从不同的捐赠者接受了FMT.
- 在传统疗法失败后,FMT作为救援治疗进行.
主要成果:
- 两位患者在FMT后的炎症标志物,临床症状和生活质量都经历了快速和持续的改善.
- 结肠镜检查结果也得到改善,表明大肠炎的解决.
- 在FMT之后,没有需要额外的免疫抑制治疗.
结论:
- 便微生物种移植 (FMT) 显示出作为耐火性免疫媒介性结肠炎 (IMC) 的安全有效的二线或三线治疗的潜力.
- 标准化FMT协议,供体查和生物库对于提高安全性和可复制性至关重要.
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