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在个性化核医学中推进内部剂量测量:在临床实践中优化放射性药物的使用

Ali H D Alshehri¹

¹Department of Radiological Sciences, College of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.

Pharmaceuticals (Basel, Switzerland)

|November 27, 2025

概括

三个蒙特卡洛模拟代码 (MCNP6,GATE,GAMOS) 使用医学内部辐射剂量 (MIRD) 形式主义准确量化了器官中吸收的辐射剂量. 这个经过验证的工具包为个性化核医学和放射性药物疗法推进了内部剂量测量.

科学领域:

核医学是一种核医学.
医学物理医学物理
计算建模计算建模

背景情况:

精确量化人体器官中放射性药物吸收的辐射剂量对于有效的核医学应用至关重要.
这些吸收剂量的直接体内测量通常是不切实际的,需要先进的计算方法.
蒙特卡洛 (MC) 模拟为模拟复杂生物系统中的辐射传输和能量沉积提供了一种强大的方法.

研究的目的:

为了比较和验证三个基于MC的模拟代码:MCNP6,GATE和GAMOS,用于内部剂量计计算.
根据医学内部辐射剂量 (MIRD) 形式,评估这些代码在量化吸收剂量的性能.
为了证明这些MC框架对于诊断和治疗放射性药物应用的适应性.

主要方法:

使用三个MC代码:MCNP6,GATE和GAMOS,进行内部剂量计模拟.
采用医学内部辐射剂量 (MIRD) 形式主义进行剂量评估.
模拟Tc-MIBI吸收在一个人形幻象的心肌中,评估在不同时间点的目标器官的剂量分布.

主要成果:

这三个MC代码都在器官特定剂量分布上表现出强烈的一致性.
在所有模拟代码中,胰腺,胆囊和脏始终获得了最高的吸收剂量.
建立了一个一致的器官剂量排名 (胰腺>胆囊>脏>脏>心脏/肝脏),证实了经验数据.

结论:

该比较分析强调了MCNP6,GATE和GAMOS在内部剂量计中的互补优势.
GATE适用于高保真性临床应用,GAMOS适用于快速原型设计,MCNP6作为基准工具.
这些MC框架提供了一套经过验证和可适应的工具包,用于在个性化核医学和放射性药物治疗开发中推进内部剂量测量.

关键词:

99mTcc 的时间.网关和GAMOS代码的代码.在MIRD的形式主义中.蒙特卡洛模拟的蒙特卡洛模拟祖巴尔的幻影是一个人.放射性药物剂量测量放射性药物剂量测量

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