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- 一种具有强大的抗癌和抗氧化潜力的植物

Justyna Stefanowicz-Hajduk¹, Anna Hering¹, Rafał Hałasa²

¹Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, 80-416 Gdańsk, Poland.

Pharmaceuticals (Basel, Switzerland)

|November 27, 2025

概括

芳香 (Coleus aromaticus) 具有强大的抗癌和抗氧化特性,特别是它的乙醇提取物,对胃癌和结肠癌细胞具有显著的活性. 这种天然产品在预防和治疗胃肠道癌症方面表现有前途.

科学领域:

植物化学植物化学
药理学药理学是指药理学的学科.
自然产品自然产品

背景情况:

胃肠道癌症 (胃癌,结肠癌) 是一个重大的全球健康挑战,治疗选择有限.
天然产品正作为潜在的化学预防药物对抗这些癌症而受到越来越多的关注.
以用途而闻名的Coleus aromaticus具有未经检查的生物和药理潜力.

研究的目的:

评估各种Coleus aromaticus提取物和果汁的抗癌,抗氧化和抗菌活性.
确定植物化学成分,包括总和黄含量,以及挥发性化合物.
为了确定胃肠癌化学预防的潜在天然治疗剂.

主要方法:

使用MTT测定对人类胃 (AGS) 和结直肠 (HCT 116) 癌细胞进行评估的抗癌活性.
通过DPPH,ABTS和降解功率测试评估的抗氧化潜力.
使用微稀释确定抗菌活性;植物化学分析包括TPC,TFC,GC-MS和GC-FID.

主要成果:

乙醇提取物表现出最强的抗癌活性 (IC50:AGS为4.94μg/mL,HCT为24.99μg/mL) 和抗氧化能力.
乙醇和乙醇/水提取物显示出强烈的抗微生物活性对克洛斯特透菌 (MIC <0.02 mg/mL).
植物化学分析显示,乙醇提取物中的高 (75.87毫克GAE/g) 和黄 (176.01毫克QE/g) 含量,卡瓦克罗尔是主要的挥发性化合物.

结论:

芳香,特别是它的乙醇提取物,显示出作为胃肠道癌症的化学预防剂的显著潜力.
该植物强大的抗癌和抗氧化特性,归因于其植物化学特征,需要进一步调查.
这项研究支持使用Coleus aromaticus在基于天然产品的癌症预防策略中.

关键词:

抗微生物药物抗微生物药物卡尔瓦克罗尔 (Carvacrol) 是一种结肠直肠癌细胞是什么气相色谱是一种气相色谱.胃癌细胞胃癌细胞总的黄酸盐含量是多少的总含量的总含量

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