自闭症中的微生物群-肠-大脑轴:关联,因果推理和干预-一个叙事审查
Zhiqiang Zhang1,2, Wenkai Kang1,2, Yu Mi1
1Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Pathogens (Basel, Switzerland)
|November 27, 2025
概括
自闭症谱系障碍 (ASD) 和肠道症状通过微生物群-肠道-大脑轴联系在一起. 本综述探讨了这种联系,评估了针对性自闭症研究的益生菌等干预措施.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出显著的异质性,通常与胃肠道 (GI) 症状同时发生.
- 在ASD中,胃肠道症状可能与行为表型相关,这表明存在生物联系.
研究的目的:
- 综合关于ASD中的微生物群-肠-大脑轴的证据.
- 区分关联与因果关系,并评估混因素.
- 总结干预措施并提出未来的研究方向.
主要方法:
- 临床,机械学和干预研究的叙述性综述.
- 从2010年1月到2025年7月的文献搜索.
- 分析通讯路径 (神经,免疫,内分泌) 和代谢物 (SCFA,二-二).
主要成果:
- 微生物群-肠-大脑轴在ASD中提供了可信的双向通信途径.
- 目前的证据经常支持关联,因果关系需要进一步调查.
- 诸如益生菌,益生菌和便微生物群移植等干预措施显示出潜力,但需要更严格的研究.
结论:
- 肠道微生物群通过微生物群-肠道-大脑轴显著影响ASD表型.
- 未来的研究应该集中在精准医学上,对患者进行分层,并针对有效干预的具体途径.
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