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Updated: Jan 10, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

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LAIV突变选择性地改变流感病毒RNA聚合酶功能,有利于转录而不是基因组合成

Justin R Leach1, Adrian Oo2, Aitor Nogales3

  • 1Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Viruses
|November 27, 2025
PubMed
概括

活体减弱型流感疫苗 (LAIV) 使用病毒RNA聚合酶子单元的突变来降低感染力. 这些突变在体温下增强了转录与复制的作用,减弱了病毒,同时保持了抗原的产生.

关键词:
这是H1N1流感.拉维夫 拉维夫 拉维夫 拉维夫流感 流感 流感 流感 流感聚合酶聚合酶是一种接种疫苗 接种疫苗

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