Limosilactobacillus fermentum IOB802通过肠道微生物群调节,防止蓝光诱导的视网膜病变
Chen Liu1, Yuqi Zhao1, Jia Li1
1College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Nutrients
|November 27, 2025
概括
乳酸细菌后生菌通过减少炎症和增强抗氧化剂来保护蓝光对视网膜损伤. 这突出了肠-视网膜轴.
科学领域:
- 眼科和微生物学
- 肠-视网膜研究轴研究
- 细胞和分子生物学 细胞和分子生物学
背景情况:
- 蓝光暴露会造成显著的视网膜光损伤,这是一个日益严重的全球健康问题.
- 乳酸细菌 (LAB) 及其代谢物为缓解视网膜损伤提供了潜在的治疗途径.
研究的目的:
- 为了评估Limosilactobacillus fermentum IOB802和Lactobacillus plantarum亚种的保护作用. 脚部IOB602针对蓝光诱导的视网膜损伤.
- 阐明涉及视网膜保护的潜在抗氧化,抗炎和微生物群调节机制.
主要方法:
- 使用ARPE-19细胞的体外研究和使用小鼠蓝光视网膜损伤模型的体内研究.
- 评估细胞活力,抗氧化酶活动,炎症性细胞因子水平,视网膜结构和紧结蛋白表达.
- 16S rDNA测序和短链脂肪酸 (SCFA) 分析分析肠道微生物群的组成和功能.
主要成果:
- 来自IOB802和IOB602的后生物在体外显著改善了细胞活力,抗氧化能力,并减少了炎症标志物.
- IOB802治疗保留了视网膜结构,增强了抗氧化防御,并在体内促进了紧结蛋白的表达.
- IOB802调节了肠道微生物群,增加了有益细菌和SCFA水平,并通过IκBα/NF-κB通路抑制了炎症.
结论:
- Limosilactobacillus fermentum IOB802及其后生物体显示出对蓝光诱导的视网膜病变具有显著的保护作用.
- 保护机制包括抗氧化,抗炎作用,以及肠视网膜轴的调节.
- 这些发现支持基于微生物组的策略来管理视网膜疾病.
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