肠神经系统的饮食调节:从分子机制到治疗应用
Xintong Wang1, Wen Zhang1, Huihui Wang1
1Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Nutrients
|November 27, 2025
概括
饮食中的物质可以调节肠道神经系统 (ENS),即"第二大脑",影响肠-大脑轴健康. 本综述探讨了多和益生菌等营养素如何影响ENS功能,并提出了未来的研究方向.
科学领域:
- 神经胃肠病学 神经胃肠病学
- 营养神经科学 营养神经科学
- 肠-大脑轴研究研究
背景情况:
- 肠道神经系统 (ENS),或"第二大脑",对于胃肠道和全身平衡至关重要.
- 肠神经系统的结构和功能完整性通过肠-大脑轴影响消化,免疫力和整体健康.
- 饮食成分越来越多地被认为有潜力以安全和可访问的方式调节ENS功能.
研究的目的:
- 系统地审查ENS解剖学,细胞成分和生理功能.
- 为了分类和描述影响ENS的关键饮食成分 (多,SCFA,氨基酸,前/益生菌).
- 检查这些食物质调节肠神经系统生理学和神经免疫平衡的机制.
主要方法:
- 对ENS结构和功能进行系统的文献综述.
- 影响内脏神经系统的饮食成分的分类和分析.
- 检查在ENS上的饮食调节的分子和生理机制.
主要成果:
- 详细概述ENS解剖学 (肌肠/粘膜下) 和细胞组件 (神经元,细胞质).
- 探索饮食中的物质,如多,SCFA,氨基酸,益生菌和益生菌及其特性.
- 阐明饮食影响ENS运动,神经元完整性和神经免疫平衡的机制.
结论:
- 饮食干预为调节ENS功能和改善健康提供了一个有希望的途径.
- 目前研究的局限性包括依赖动物模型和不明确的人类机制.
- 未来的方向强调精准医学,临床翻译和针对性ENS调制的先进技术.
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