维生素D状态作为感知压力的晚期怀孕生物标志物
Maya F Andrade1, Anjali G Borsum1, Mathew J Gregoski2
1College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Nutrients
|November 27, 2025
概括
维生素D (VD) 状态,以血清25-基维生素D [25(OH) D]度来衡量,可以作为怀孕期间压力的生物标志物. 较高的VD水平显示,在预测7个月内感知压力较低的意义上趋向于显著.
科学领域:
- 孕产妇健康 孕产妇健康
- 营养生物化学 营养生物化学
- 心理神经免疫学 心理神经免疫学
背景情况:
- 怀孕期间的压力对母亲和胎儿的健康有很大的影响.
- 社会人口统计学和生物学因素与怀孕压力有关.
- 维生素D (VD) 作为怀孕期间压力生物标志物的作用尚未得到充分研究.
研究的目的:
- 调查社会人口学因素,维生素D状态 (血清25-氧维生素D[25(OH) D]) 和孕妇感知压力之间的关系.
- 要确定25(OH) D度是否与怀孕期间感知到的压力水平有关.
主要方法:
- 来自凯洛格怀孕性性疾病研究中的232名孕妇的后期分析.
- 在2,5和7个月收集感知压力量表 (PSS-10) 分数和25...OH) D度.
- 使用后勤回归来识别与中度至高度感知压力相关的因素.
主要成果:
- 早期怀孕:婚姻状况,大学教育和较低的BMI与较低的压力相关;黑人种族与较高的压力相关.
- 第7个月:较高的血清25(OH) D度是较低感知压力的显著单变预测因子 (p=0.002).
- 7个月的多变量模型显示,25...OH) D接近显著性 (p=0.053) 预测感知压力.
结论:
- 种族,婚姻状况,教育和BMI等社会人口统计因素与怀孕早期的压力有关.
- 维生素D状况,以25...OH) D水平表示,成为与怀孕晚期感知压力的重要因素.
- 需要在干预试验中进行进一步的研究,以证实体内疾病作为怀孕期间压力生物标志物的作用.
相关概念视频
Role of Skin in Vitamin D Synthesis
7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
Introduction to Stress and Lifestyle
496
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
496
Physiological Foundation of Stress
518
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
518
Psychological Responses to Stress
459
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
459
Psychoneuroimmunology: Diabetes and Cancer
412
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
412
Psychoneuroimmunology: Cardiovascular Disease
368
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
368


