作为循环节调节器的鲁维护了骨肌肉的线粒体功能,并减少了氧化应激,以保护体外和体外的D-银河糖诱导的衰老
Yoonha Choi1, Suhyeon Lee2, Eunju Kim2
1Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Republic of Korea.
Nutrients
|November 27, 2025
概括
鲁丁是一种抗氧化剂黄类化合物,通过改善昼夜节律,减少氧化应激和增强线粒体功能来对抗骨肌肉衰老. 这种天然化合物在治疗与年龄相关的肌肉衰退和肉症方面表现有前途.
科学领域:
- 老年学是一门学科.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 骨肌肉的衰老包括分化功能受损,昼夜节律受损,氧化应激和线粒体功能障碍.
- 鲁丁是一种类黄素,具有抗氧化性质,但其对肌肉昼夜调节和平衡的影响尚不清楚.
研究的目的:
- 研究素对C2C12神经管和C57BL/6小鼠中D-银糖诱导的衰老的影响.
- 为了确定 rutin 是否可以缓解细胞衰老,改善肌体分化,并恢复衰老肌肉中的昼夜节律.
主要方法:
- 在体外:C2C12神经管经过D-银糖和/或鲁丁的处理.
- 在体内:C57BL/6小鼠接受了D-银糖的治疗,并通过口服 gavage补充了鲁丁.
- 评估了细胞衰老,肌原分化,昼夜基因表达,氧化应激标记,线粒体功能和肌肉性能.
主要成果:
- D-银河糖诱导衰老,分化受损,昼夜节律受损,氧化应激增加和线粒体功能障碍.
- 鲁恢复了肌管的形成,使昼夜基因表达正常化 (Per2,Rorc),减少了氧化应激标志物 (ROS,MDA),并改善了线粒体功能 (ATP,膜潜力).
- 在体内,增强了肌肉性能和氧化能力,特别是在晚上,并使核心时钟基因节律正常化.
结论:
- 鲁丁通过调节昼夜节律,减少氧化应激,改善线粒体功能来减轻D-银糖诱导的细胞衰老.
- 轮对肌肉性能和昼夜调节的体内影响表明,它是治疗骨肌肉衰老和肉症的有希望的治疗策略.
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