益生菌短期营养对儿童口腔健康参数的影响:试点随机对照试验
Edouard Starck1, Vanessa Machado1, João Botelho1
1Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.
Nutrients
|November 27, 2025
概括
这项试点研究发现,为期30天的多菌株益生菌补充剂是安全的,并被儿童接受,但没有显著改善牙损伤指标. 需要进一步的长期研究来确认益生菌对儿科口腔健康的益处.
科学领域:
- 微生物学 微生物学
- 儿科牙科 儿科牙科
- 预防性牙科 预防性牙科
背景情况:
- 突变性菌株 (S. mutans) 通过生物膜酸性和牙去矿化导致牙损伤.
- 传统的空预防方法包括机械斑块控制和饮食改变.
- 益生菌为调节口腔微生物群提供了一个潜在的辅助策略.
研究的目的:
- 评估多菌株益生菌对儿童牙指标的短期影响.
- 评估与脏病相关的临床和微生物学参数.
- 为了确定益生菌在儿科患者群体中的安全性和可接受性.
主要方法:
- 一项为期30天,双盲,随机,安慰剂控制的试验,涉及40名儿童 (6-14岁).
- 参与者接受了益生菌或安慰剂.
- 评估的牙指数 (GI),斑块指数 (PI),国际虫检测和评估系统 (ICDAS),唾液pH,缓冲容量和*S. mutans*度.
主要成果:
- 益生菌干预是安全和高度可接受的,没有不良事件.
- 在临床或微生物学参数 (p > 0.05) 中没有观察到统计学意义上的差异.
- 趋势表明唾液pH值较高,缓冲能力提高,益生菌组中的*S. mutans*数量减少.
结论:
- 儿童短期 (30天) 服用益生菌补充剂是安全的,耐受性良好.
- 没有实现口腔健康参数的统计学显著改善.
- 需要进行更大规模,更长期的研究,以探索益生菌作为儿童空预防的辅助剂的有效性.
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