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哺乳婴儿口腔微生物组的发展与人乳寡糖的度和摄入量有关
Roaa A Arishi1,2,3,4, Ali S Cheema5, Jacki L McEachran1,2,3
1School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009, Australia.
Nutrients
|November 27, 2025
概括
人类牛奶寡糖 (HMO) 影响婴儿口腔微生物群的多样性和特定的细菌,如Neisseria和Streptococcus. 虽然在统计学上显著,但HMO对口腔微生物发育的生物学影响是有限的.
科学领域:
- 微生物学 微生物学
- 人类营养人类营养
- 婴儿健康 婴儿健康
背景情况:
- 人类母乳寡糖化物 (HMO) 对婴儿肠道微生物组的发展至关重要.
- 在塑造婴儿口腔微生物群的过程中,HMO的作用尚不清楚.
- 本研究探讨了HMO与婴儿口腔微生物组组成之间的关系.
研究的目的:
- 调查HMO度与婴儿口腔微生物组之间的关联.
- 检查婴儿HMO摄入量与口腔微生物组组成之间的联系.
- 了解特定HMO对婴儿口腔微生物发育的影响.
主要方法:
- 分析了56名纯母乳和主要母乳养的婴儿 (2个月大) 的口腔样本.
- 用全长的16S rRNA基因测序来分析口腔微生物组.
- 分析了配对母乳HMO成分和婴儿每日HMO摄入量计算.
主要成果:
- HMO 3FL和LNFPIII度与口腔香农的多样性和丰富性有负相关性.
- LNFPII的度和摄入量与Neisseria subflava丰度的增加相关.
- DFLNT和DFLNH摄入量与Streptococcus parasanguinis的丰富性有积极的关联,尽管效果大小适度.
结论:
- 婴儿口腔微生物对婴儿口腔微生物群发育具有统计学上显著但生物学上有限的影响.
- 特定的HMO会影响关键口腔细菌如尼塞里亚菌和链球菌的丰富性.
- 研究结果提供了关于人乳成分如何塑造早期口腔微生物群落的见解,支持母乳养干预措施.
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