建立一个名谱来预测瘤病房肺栓塞风险:一项回顾性研究
Qiu Liuyi1, Chen Tenggao2, Lu Yifang3
1Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang Province, China.
Medicine
|November 27, 2025
概括
这项研究开发了一种名谱,用于预测癌症患者的肺栓塞 (PE) 风险. 该模型使用中性粒细胞数,性别,血压,手术状态和D-二次体来更好地评估风险和预防策略.
科学领域:
- 在瘤学瘤学.
- 肺部医学 肺部医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 肺栓塞 (PE) 对癌症患者具有显著的死亡风险.
- 准确的PE风险预测对于瘤学环境中的及时干预和管理至关重要.
研究的目的:
- 开发和验证用于预测瘤病房内患者的PE风险的诺米克图.
- 确定与癌症患者PE相关的关键临床和实验室因素.
主要方法:
- 在瘤科 (2012-2021) 中,对512名疑似PE患者进行了回顾性分析.
- 使用后勤回归和LASSO开发名图,并通过ROC,校准和决策曲线进行验证.
- 包括诸如中性粒细胞计数,性别,缩血压,手术状态和D-二次数水平等特征.
主要成果:
- 纳米图识别了5个关键预测因素:中性粒细胞数量,性别,缩血压,手术状态和D-二次数.
- 获得的AUC为0.758 (培训) 和0.702 (验证),校准良好,具有临床效用.
- 对于PE风险,已经证明了高灵敏度 (85.58%) 和负预测值 (55.71%).
结论:
- 一个新的,经过验证的诺米图有效地预测了瘤学患者的PE风险.
- 该模型有助于选择适当的预防策略,并可能减少不必要的成像.
- 有助于改善患者管理,并减少与诊断程序相关的不良影响.
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