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1400个循环代谢物和自发流产之间的因果关系:双向的双样本孟德尔随机化研究

Xuan Zhou^1,2, Yu-Xuan Fang³, Da-Wei Zhang^1,2

¹Henan University of Chinese Medicine, Zhengzhou, China.

|November 27, 2025

概括

代谢障碍可能会因果地影响自发流产 (SA). 这项研究确定了与SA风险相关的特定循环代谢物,为早期妊娠损失提供了潜在的生物标志物.

科学领域:

代谢学代谢学代谢学
生殖健康生殖健康
遗传流行病学遗传流行病学

背景情况:

自发性流产 (SA) 影响10-15%的怀孕,代谢联系不明.
调查代谢物在SA中的因果作用对于了解早期妊娠损失至关重要.

研究的目的:

通过使用孟德尔随机化来评估1400种血代谢物和自发流产 (SA) 之间的因果关系.
确定可能在SA.的病理生理学中起因作用的特定代谢物.

主要方法:

双向的双样本孟德尔随机化 (MR) 分析.
利用了1400种代谢物的全基因组关联研究数据和大规模的SA总结统计数据 (FinnGen R12).
采用逆方差加权,MR-Egger和加权中位数方法,并对稳定性进行敏感性分析.

主要成果:

三十六种循环代谢物显示出与SA的显著因果关联.
甲基胺显示具有保护作用 (OR,0.89).
甘油与卡尼丁的比率 (OR,1.07),1-甲基-5-伊米达乙酸 (OR,1.09) 和咖啡因与西奥菲林的比率 (OR,1.08) 显示了增加风险的效应.

结论:

提供了在SA.中特定循环代谢物的因果作用的遗传证据.
确定了用于生殖风险分层的潜在生物标志物,以及针对早期妊娠损失的有针对性的干预措施.
这些发现为自发堕胎的病理生理学提供了新的机制性见解.

关键词:

门德尔的随机化有关因果推理的推理.代谢过程中的代谢.代谢产物的代谢产物这是自发流产.

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