叶酸对重度抑郁症的因果作用:孟德尔随机化,LDSC和局部化分析
Dele Liu1, Fengxiang Liao, Yanping Xiong
1Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Medicine
|November 27, 2025
概括
高水平的叶酸摄入量显著降低了主要抑郁症 (MDD) 的风险. 这项研究没有发现其他宏观营养素或B族维生素 (B6,B12) 与MDD风险之间的因果关系.
科学领域:
- 营养精神病学 营养精神病学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 饮食干预措施在减轻主要抑郁症 (MDD) 风险方面表现有前途.
- 具体的宏观营养素和维生素B摄入量与MDD之间的因果关系仍然不确定.
研究的目的:
- 调查宏观营养素和维生素B (B6,B12,叶酸) 摄入对MDD风险的因果关系.
- 探索与叶酸和MDD相关的遗传相关性和甲基化影响.
主要方法:
- 在338,111个人中进行单变门德尔随机化分析.
- 链接不平衡得分回归和局部化分析.
- 探索叶酸对MDD的DNA甲基化影响.
主要成果:
- 高水平的叶酸因果关系与降低MDD风险有关 (OR=0.010).
- 蛋白质,脂肪,碳水化合物,维生素B6或维生素B12摄入量与MDD没有发现因果关系.
- 鉴定了叶酸和MDD之间的遗传相关性和共同因果变异,以及甲基化位点的关联.
结论:
- 叶酸补充剂显示出对重度抑郁症有显著的保护作用.
- 聚焦叶酸的营养策略可能对预防MDD有益.
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