氧化平衡得分与高血压患者全因死亡率之间的关系:一项观察性研究
Jie Li1, Yiming Zeng2, Yue Guan2
1Department of Cardiology, Ruijin-Hainan Hospital Shanghai Jiao Tong University School of Medicine (Hainan Boao Research Hospital), Qionghai, China.
Medicine
|November 27, 2025
概括
综合饮食和生活方式因素的更高氧化平衡得分 (OBS) 与美国高血压成年人全因死亡率的降低有关. 这表明OBS可能有助于对高血压患者的预后风险评估.
科学领域:
- 营养流行病学 营养流行病学
- 心血管健康 心血管健康
- 氧化应激的生物标志物
背景情况:
- 通过氧化平衡得分 (OBS) 表示的全身氧化应激受饮食和生活方式因素的影响.
- 高血压是心血管疾病和死亡的主要危险因素.
- 了解影响高血压患者死亡率的因素对于公共卫生至关重要.
研究的目的:
- 调查氧化平衡评分 (OBS) 与美国高血压成年人全因死亡率之间的关联.
- 探索OBS作为高血压预后风险评估工具的潜力.
主要方法:
- 氧化平衡评分 (OBS) 计算使用16种饮食营养素和3种生活方式因素.
- 评估非线性关系时使用了光滑线.
- 使用卡普兰-梅尔曲线,多变量考克斯回归,竞争风险模型和子组分析来评估死亡风险.
主要成果:
- 较高的OBS水平与高血压成年人全因死亡率显著降低有关 (HR=0.87,95% CI:0.78-0.96).
- 敏感性分析和竞争风险模型证实了高OBS和降低死亡率之间的保护性关联,包括高血压相关的死亡率.
- 在OBS和全因死亡率之间观察到非线性关系.
结论:
- 较高的OBS与美国高血压成年人全因和高血压相关死亡率的降低有关.
- OBS在高血压患者的预后风险评估中显示出潜在的有用性.
- 将饮食和生活方式因素整合到一个单一的分数中,可能会为健康结果提供有价值的见解.
相关概念视频
01:28Factors affecting Blood pressure
6.3K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
6.3K
01:25Errors occurring during blood pressure monitoring
1.3K
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
1.3K
01:18Hypertension and Regulation of Blood Pressure
3.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.6K
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
443
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
443
01:29Hypertension II: Pathophysiology
708
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
708
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
578
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
578