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Updated: Jan 10, 2026

Improved Polymerase Chain Reaction-restriction Fragment Length Polymorphism Genotyping of Toxic Pufferfish by Liquid Chromatography/Mass Spectrometry
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高分子量未知化合物的精确质量差异从已解决的同位素分布:寡核酸杂质

Stilianos G Roussis1

  • 1Ionis Pharmaceuticals Inc, Analytical Development & Quality Control, 2855, Gazelle Ct., Carlsbad, California 92010-6670, United States.

Analytical chemistry
|November 27, 2025
PubMed
概括

使用质谱测量来确定高分子量 (HMW) 化合物的公式具有挑战性. 新的方法可以准确计算同位素分布之间的质量差异 (ΔM),简化了像寡核酸等复杂分子的公式识别.

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