绘制世卫组织基本药物的治疗多功能性:对非标签性指示进行系统分析
Ramya Kateel1, Shreya Hegde1, Sadhana Holla2
1Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Therapeutic advances in drug safety
|November 27, 2025
概括
非标签的基本药物的处方是常见的,60%的世界卫生组织EML药物用于未经批准的适用症. 大多数用途的证据有限,尽管许多都包含在临床指南中.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 基于证据的医学 基于证据的医学
背景情况:
- 非标签处方是一种全球性的临床实践.
- 世界卫生组织基本药物清单 (WHO EML) 药物的非标签使用数据有限.
- 世卫组织EML对医疗保健系统至关重要,特别是在低收入和中等收入国家.
研究的目的:
- 系统地分析非标签药物使用的流行情况.
- 检查这些用途的证据基础和指南支持.
- 评估2023年世卫组织EML上药物的非标签性适用性.
主要方法:
- 描述性的横截面观测研究.
- 对世卫组织EML药物的UpToDate Lexidrug数据库的分析.
- 提取了FDA批准的指示,非标签用途,证据水平 (A,B,C,G) 和指导方针的包含.
主要成果:
- 60%的世卫组织EML药物有非标签用途.
- 传染病 (30.5%) 和瘤病 (25.2%) 的非标签流行率最高.
- 大多数非标签用途具有C级 (32%) 或B级 (30%) 证据;只有11%具有A级证据.
- 64%的非标签用途在临床指南中,通常没有指定的证据水平.
结论:
- 这项研究提供了第一个对世卫组织EML药物的非标签用途的全面分析.
- 基本药物被广泛重新使用,但支持证据的质量不同.
- 这些发现强调需要评估支持非标签使用基本药物的证据.
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