来自Rehmannia glutinosa的catalpol-a化合物可以通过调节肠道微生物群和内源代谢途径来改善超脂血症
Xinfeng Pei1, Weichao Dong2, Yingying Yu2
1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in microbiology
|November 27, 2025
概括
卡塔尔波尔 (Catalpol) 是来自Rehmannia glutinosa的化合物,通过调节肠道微生物群并恢复超脂血症 (HL) 鼠的代谢平衡,有效降低血脂. 这项研究揭示了其作为HL新型治疗药物的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 卡塔尔波尔 (Catalpol) 来自Rehmannia glutinosa,以其降低葡萄糖的作用而闻名.
- 它对高脂血症 (HL) 的潜在治疗益处仍然未被探索.
研究的目的:
- 为了研究catalpol的降脂作用.
- 在超脂血症模型中探索catalpol对肠道微生物群和代谢途径的影响.
主要方法:
- 在使用高脂肪饮食 (HFD) 的Sprague-Dawley大鼠中诱导了超脂血症.
- 脂质降低功效被生物化学评估.
- 用16S rRNA基因测序分析了肠道微生物组成.
- 使用UHPLC-Q Exactive Orbitrap MS和非向代谢组的代谢物被确定.
主要成果:
- 卡塔尔波尔显著降低了脂质水平和肝脂质过氧化.
- HFD改变了肠道微生物群 (增加了Firmicutes,减少了Bacteroidetes),catalpol治疗可以逆转.
- 卡塔尔波尔使18种由HFD改变的内源代谢物正常化.
- 乳酸菌的丰富度与catalpol的抗HL效果有积极的相关性; 瑞丁作为一种潜在的生物标志物出现了.
结论:
- 在超脂血症模型中,Catalpol表现出显著的降脂效应.
- 这些效应通过调节肠道微生物组成和恢复血代谢平衡来调节.
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