产前臭氧暴露与儿童肺功能受损的因果关系
Zhiqing Chen1,2,3, Mei Jiang4, Cuiling Wu1,2
1Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
Environment & health (Washington, D.C.)
|November 27, 2025
概括
产前暴露于臭氧 (O3) 可能会损害儿童的肺功能. 怀孕期间较高的臭氧水平增加了肺功能受损的风险,特别是在高温和低绿色的情况下.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
背景情况:
- 人类肺部的发育是复杂的.
- 以前的研究表明,产前臭氧暴露与肺功能下降之间存在联系,但因果关系尚未确定.
研究的目的:
- 为了调查产前暴露于环境臭氧和儿童肺功能受损之间的因果关系.
主要方法:
- 这是一项针对1058名儿童的横截面队列研究.
- 进行了肺功能测试.
- 用通用线性模型,通用倾向得分和反向概率加权来分析臭氧暴露 (MDA8 O3) 和肺功能.
主要成果:
- 产前臭氧暴露量增加10μg/m3与肺功能受损的概率增加有关 (总体OR为1.52,第一季度为1.22,第三季度为1.47).
- 负面影响被高环境温度和低住宅绿色放大,并被相对湿度减弱.
结论:
- 产前暴露于高臭氧度可能导致儿童期肺功能受损.
- 温度,湿度和绿色等环境因素改变了臭氧对肺部发育的影响.
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