父母产后抑郁症和后代自闭症谱系障碍之间的关联
Weiyao Yin1, Abraham Reichenberg2,3,4, Sven Sandin1,2,3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Frontiers in psychiatry
|November 27, 2025
概括
父母产后抑郁症 (PPD) 显著增加了儿童患自闭症谱系障碍 (ASD) 的风险. 当父母都患有PPD时,这种风险更高,这表明他们有共同的遗传因素.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 儿科 儿科 儿科
背景情况:
- 产后抑郁症 (PPD) 影响高达20%的母亲.
- 父母的精神病史与后代的神经发育状况有关.
- 关于PPD和自闭症谱系障碍 (ASD) 风险的研究有限,特别是父亲的PPD.
研究的目的:
- 为了研究父母的PPD和后代的ASD风险之间的关联.
- 探索父亲PPD的影响,以及父母都有PPD对ASD风险的综合影响.
主要方法:
- 在瑞典 (1997-2022) 进行的一项全国性前性队列研究包括1,781,349名活产儿.
- 考克斯回归量化了父母的PPD和ASD诊断之间的关联.
- 调整了诸如抑郁症史和其他父母精神病因素等混因素.
主要成果:
- 患有PPD母亲的孩子患ASD的风险增加了2.56倍 (调整HR为1.53).
- 患有PPD父亲的孩子患ASD的风险增加了2.59倍 (调整HR为1.71).
- 两个父母均被诊断患有PPD的孩子的ASD风险增加了5.54倍 (调整HR 2.19).
结论:
- 父母的PPD与后代ASD风险增加有关.
- 这种关联部分是由抑郁症史和其他父母精神病因素解释的.
- 当父母都患有PPD时,风险增加表明共同的遗传影响.
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