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对SREBP1的DysUFMylation通过重编程脂质代谢来促进肝细胞癌的进展

Xukang Gao1,2,3, Zeping Han1,2,3, Min Xu4

  • 1Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of clinical and translational hepatology
|November 27, 2025
PubMed
概括

UFMylation 破坏了固醇调节元素结合蛋白1 (SREBP1) 的稳定,这是肝癌进展的关键因素. 抑制这一过程为肝细胞癌 (HCC) 提供了一个新的治疗策略.

关键词:
在HCC中,HCC是HCC,HCC是HCC.肝细胞癌是肝细胞癌.在SREBP1中,固醇调节元件结合蛋白 1 1 固醇调节元件结合蛋白在UFL1中,UFL1是UFL1.在UFMylation中进行化.乌比奎丁折叠修饰剂1-特异性联酶1-特异性联酶1

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