关于与向药物和肝细胞癌免疫检查点抑制剂相关的肝损伤管理的共识 (2024版)
Suxian Zhao1, Jie Li2, Lingdi Liu1
1Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Journal of clinical and translational hepatology
|November 27, 2025
概括
肝癌的全身治疗可以导致肝损伤. 这一共识为肝细胞癌患者的向药物和免疫检查点抑制剂的肝损伤管理提供了临床指导.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 系统性治疗,包括分子向药物和免疫检查点抑制剂,越来越多地用于肝细胞癌.
- 肝损伤是与这些疗法相关的常见和重大不良事件.
- 管理这种药物诱导性肝损伤 (DILI) 需要专门的知识和标准化的方法.
研究的目的:
- 在肝癌患者中制定诊断,预防和治疗向药物和免疫检查点抑制剂诱导的肝损伤的实用建议.
- 为临床医生提供决策指导,以管理肝细胞癌中肝脏不良反应.
- 建立关于与新型肝癌全身疗法相关的肝损伤管理的共识.
主要方法:
- 系统性癌症治疗与肝损伤相关的国内和国际文献的系统审查和分析.
- 专家共识由中国肝病学学会,中国医学协会制定.
- 根据总结的证据和专家意见制定临床指南.
主要成果:
- 鉴定向药物和免疫检查点抑制剂造成的肝损伤的常见模式和危险因素.
- 开发药物诱导的肝损伤的诊断标准和监测策略.
- 预防措施和治疗干预措施的建议,包括药物戒断,皮质类固醇和其他支持性护理.
结论:
- 肝损伤的有效管理对于肝细胞癌的全身疗法的安全和持续应用至关重要.
- 该共识为临床医生提供了一个框架,通过解决与肝脏相关的毒性来优化患者的治疗结果.
- 遵守这些准则可以改善肝癌患者的向和免疫治疗的益处风险比率.
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