在腹腔透析患者中,先前存在的心血管疾病和高脂血症以及死亡率
Panpan Cao1, Xiaojiang Zhan2, Yueqiang Wen3
1Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in endocrinology
|November 27, 2025
概括
患有心血管疾病 (CVD) 和高脂血症的持续门诊腹膜透析 (CAPD) 患者面临明显更高的全因死亡风险. 管理失脂症对于改善这一群体的长期结果至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 和脂质失调是连续门诊腹腔透析 (CAPD) 患者常见的并发症.
- 预先存在的心血管疾病和失脂症对CAPD患者死亡风险的综合影响需要进一步调查.
研究的目的:
- 评估先前存在的心血管疾病 (CVD) 和失脂症与CAPD患者所有原因死亡率之间的关联.
- 确定心血管疾病和脂质障碍症的共存是否会加剧CAPD患者死亡风险.
主要方法:
- 一项多中心的回顾性队列研究,涉及2005年至2018年期间新诊断患有CAPD的2939名患者.
- 患者根据先前存在的心血管疾病和高脂血症状况进行了分类.
- 全因死亡率是主要结果,随访时间为2019年6月30日,使用missForest归算方法用于缺失数据.
主要成果:
- 单独患有先前存在心血管疾病的患者,全因死亡风险增加1.41倍.
- 与对照组相比,先前患有心血管疾病和高脂血症的患者有1.47倍的全因死亡风险.
- 单独的高脂血症并没有显著增加死亡风险 (HR 0.98).
结论:
- 预先存在的心血管疾病和高脂血症的同时存在与CAPD患者全因死亡率的增加显著相关.
- 这些发现强调了在患有心血管疾病的CAPD患者中管理失脂症的重要性.
- 协同疾病的积极管理可以改善CAPD患者的长期存活率.
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