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在55岁以下的乳头甲状腺癌患者中预测肺转移的诺莫图

Huiyun Yang¹, Qiuqin Qian^1,2, Yanling Li¹

¹Department of Nuclear Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha, China.

Frontiers in endocrinology

|November 27, 2025

概括

一个新的诺米图有助于预测年轻的乳头甲状腺癌 (PTC) 患者的肺转移风险. 在这个人群中,BRAF V600E突变与肺转移的风险较低有关.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
医学诊断医学诊断医学诊断

背景情况:

乳头甲状腺癌 (PTC) 是最常见的甲状腺癌类型.
肺转移是PTC患者结局的一个重大问题.
需要预测工具来评估转移风险,特别是在年轻人群中.

研究的目的:

开发和验证用于预测PTC患者55岁以下患者肺转移风险的诺米克图.
确定与年轻PTC患者肺转移相关的遗传和临床因素.

主要方法:

追溯收集了243名55岁以下PTC患者的数据.
分为培训 (n=170) 和验证 (n=73) 队列.
单变量和多变量逻辑回归分析以确定预后因素.
使用C指数,AUC,DCA和校准曲线构建和验证一个名ogram.

主要成果:

确定T阶段,单边甲状腺干扰,TERT突变和BRAF突变是独立的预后因素.
诺米图实现了高预测准确度,C指数为0.89 (培训) 和0.88 (验证).
该模型表现出有利的AUC,DCA和校准,灵敏度为0.829,特异性为0.793,截止值为0.229.

结论:

一个经过验证的诺姆图有效预测年轻PTC患者的肺转移风险.
诺米图可以帮助临床医生进行风险分层和治疗规划.
遗传因素,包括BRAF和TERT突变,在转移中起着至关重要的作用.

关键词:

肺部转移是肺部转移的原因之一.这是下一代测序.这个名字是名ogramogram.预后预后预后甲状腺癌是一种癌症.

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