周围静脉注射高血压盐水的安全性:系统性审查和元分析
Sih-Shiang Huang1,2, Chih-Wei Sung1,3, Chien-Tai Huang1,3,4
1Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Frontiers in medicine
|November 27, 2025
概括
周围高血压盐水是一种安全有效的替代方案,用于治疗低血和增加的内压力. 这次审查发现输液相关并发症的发病率很低,支持其更广泛的临床使用.
科学领域:
- 紧急医疗 紧急医疗
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压盐水对于治疗症状性低血压和内压升高 (IICP) 是必不可少的.
- 传统上通过中央静脉导管 (CVC) 施用,外周施用提供了更快的替代方案,降低了CVC相关的风险.
- 本综述专门研究了外周高血压盐水输注的安全性,重点关注不良事件.
研究的目的:
- 为了评估外周给药的高血压盐水的安全性和有效性.
- 评估与外周高血压盐水管理相关的输液相关不良事件的发生率.
- 为了比较外周和中央静脉注射高血压盐水的安全性,
主要方法:
- 在MEDLINE,Embase和Cochrane图书馆进行了系统的文献搜索,直到2024年12月.
- 包括在内的研究报告了在外周高血压盐溶液给药后发生的,透,扩散和血栓形成.
- 使用纽卡斯尔-太华尺度和偏差风险2工具评估了研究质量,并注册了PROSPERO (CRD42024612330).
主要成果:
- 分析了13项涉及2354名成年患者的研究,显示偏差风险较低.
- 综合的发病率为:风2.3%,入/扩张2.1%和血栓形成0.8%.
- 大多数并发症都是轻微的,并保守地管理,这表明了有利的安全性.
结论:
- 周围高血压盐水是CVC安置的安全替代品,特别是在紧急情况下.
- 低并发症率支持更广泛的临床采用,使及时治疗和最小化中央访问风险.
- 研究结果表明,在指导方针中考虑外周高血压盐水作为一线选择,以改善患者的治疗结果.
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