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一个逐步的功能注释和昆虫化学感知蛋白的结构建模的计算协议

Rajeswari Kalepu¹, Azzmer Azzar Abdul Hamid², Maizom Hassan¹

¹Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.

|November 27, 2025

概括

本研究介绍了一种计算协议,用于识别,注释和建模昆虫的化学感知蛋白,如味觉受体,帮助害虫管理策略.

科学领域:

昆虫分子生物学昆虫分子生物学
计算生物学是一种计算生物学.
结构生物学是结构生物学.

背景情况:

化学感知蛋白对于昆虫的行为至关重要,但实验性结构很少,特别是在害虫物种中.
研究这些蛋白质对于理解昆虫生态和开发害虫控制方法至关重要.

研究的目的:

提出一种可复制的计算协议,用于识别,功能性注释和结构性建模昆虫化学感知蛋白.
用红棕虫 (Rhynchophorus ferrugineus) 的味觉受体来证明该协议的实用性.

主要方法:

将公开可用的序列数据与OmicsBox集成为功能注释.
使用ColabFold进行高可信度蛋白质结构预测.
对各种昆虫数据集应用的逐步框架的开发.

主要成果:

建立了一个简化的工作流,将功能注释和结构预测结合起来.
该协议为味觉受体生成结构可靠的蛋白质模型.
该框架广泛适用于各种昆虫物种,包括非模型生物.

结论:

该协议允许对昆虫的化学感知蛋白进行可复制的研究,桥接注释和结构特征.
生成的模型适用于下游应用,如联体对接和分子动力学模拟.
这种方法支持开发新的害虫管理策略.

关键词:

生物控制生物控制这是生物信息学协议.科拉布折叠味觉受体是一种味觉受体.这就是OmicsBoxBox的意义.害虫管理害虫管理害虫管理蛋白质结构预测蛋白质结构预测红棕虫 (Rhynchophorus ferrugineus) 是一种有着红棕虫的动物.

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