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球状板:一种可扩展的平台,用于生产组织膜结构.

Quang Bach Le1, Hariharan Ezhilarasu1, Weng Wan Chan1

  • 1Biomanufacturing Technology (BMT)/Bioengineering & Automation (BE&A), Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore.

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概括
此摘要是机器生成的。

这项研究引入了一种新的,可扩展的方法,用于使用框架和网状系统将细胞球体组装成薄组织板. 这种无脚手架的方法可以控制厚度和有效的营养扩散,用于组织工程应用.

关键词:
生物工程是生物工程.生物制造 生物制造 生物制造软骨 软骨是一种软骨.细胞球形状的细胞.细胞疗法是一种细胞疗法.介质细胞干细胞 介质细胞干细胞组织工程是组织工程.组织膜的组织膜.

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科学领域:

  • 组织工程是组织工程.
  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.

背景情况:

  • 使用细胞球形体的自下而上的组织工程模仿了本地组织环境.
  • 现有的球形组装方法缺乏对几何,可扩展性和吞吐量的控制.
  • 开发可扩展和可控制的方法对于推进组织工程至关重要.

研究的目的:

  • 提出一种强大且可扩展的方法,用于将细胞球体组装成薄而平面的组织片.
  • 为了证明这种方法在制造软骨组织结构方面的实用性.
  • 为产生膜状组织用于研究和治疗提供一个实用的平台.

主要方法:

  • 细胞球体组装在两个灵活的网格之间,由一个框架保持.
  • 框架和网格系统指导球形融合,控制厚度,并确保营养交换.
  • 人类介质干细胞被用来创建带质软骨组织.

主要成果:

  • 一种薄而平面的球形板组织结构成功地被制造出来.
  • 该方法允许控制组织厚度和均的球形融合.
  • 由此产生的无脚手架的结构易于处理,并且可以移植.

结论:

  • 描述的框架和网格方法为基于球体的组织工程提供了一个可扩展和强大的方法.
  • 这种技术有助于创建用于各种应用的薄薄的,类似膜的组织结构.
  • 该方法克服了以前球形组装技术的局限性,提高了组织工程能力.