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保护性使用的阿尔法平烯在甲基酸盐诱导的氧化性肺损伤在老鼠中的保护性使用

Berna Tezcan Yavuz¹, Emel Kabartan², Selma Cirrik³

¹Faculty of Medicine, Department of Histology and Embryology, Giresun University, 28200, Giresun, Turkey.

Toxicology research

|November 27, 2025

概括

一种天然的抗氧化剂阿尔法平宁通过减少氧化应激和亡来保护免受美托雷克萨特诱导的肺损伤. 这项研究强调阿尔法平宁作为减轻化疗相关肺毒性的潜在治疗剂.

科学领域:

药理学和毒理学药理学和毒理学
自然产品化学自然产品化学
呼吸系统医学呼吸系统医学

背景情况:

甲基 (MTX) 是一种重要的抗癌药物,但其长期或高剂量使用可能会导致严重的肺毒性.
MTX诱导的肺损伤的特征是氧化应激,炎症和亡,导致严重的组织损伤.
具有抗氧化和抗炎性能的天然化合物,如阿尔法烯,正在探索其保护作用.

研究的目的:

在大鼠模型中评估Alpha Pinene对甲二甲酸诱导的肺损伤的保护潜力.
为了研究阿尔法平宁对氧化应激,亡和MTX暴露后肺部组织学变化的影响.

主要方法:

成年雄性大鼠被分为五个组:控制组,载体组,MTX,Alpha Pinene和MTX + Alpha Pinene.
动物接受了14天的治疗,MTX剂量为20 mg/kg,Alpha Pinene剂量为50 mg/kg/天.
用H&E和Masson的三色染料分析了肺组织的氧化应激标志物 (SOD,CAT,MDA),亡标志物 (APAF-1,Caspase-3),热冲击蛋白70水平和组织损伤.

主要成果:

阿尔法平宁显著缓解了MTX诱导的氧化应激和亡标志物的增加.
用阿尔法平宁的治疗降低了热冲击蛋白70的水平,MTX提高了这一水平.
组织学检查显示,Alpha Pinene可以预防严重的肺损伤,包括膜上皮损伤,拥堵和炎症,同时减少纤维化和.

结论:

阿尔法平宁在老鼠中表现出显著的保护作用,防止急性甲二甲酸诱导的肺毒性.
保护机制包括减少氧化应激,亡和肺组织中的炎症反应.
阿尔法烯是一种有前途的天然剂,可用于预防或治疗与甲索相关的肺损伤.

关键词:

阿尔法皮内皮内皮内热冲击蛋白质 70 70 热冲击蛋白质甲基特雷克萨酸盐的使用方法氧化性肺损伤氧化性肺损伤

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