与HPV疫苗相关的甲状腺不良事件:时间模式和报告趋势
Liying Song1, Jingkai Di2, Jiaolin Fan1
1Department of Thyroid Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Frontiers in pharmacology
|November 27, 2025
概括
人类乳头瘤病毒 (HPV) 疫苗接种可能与甲状腺疾病如甲状腺功能低下症和自身免疫性甲状腺炎有关. 需要进一步的研究来证实这种关联并了解风险.
科学领域:
- 药物监督 药物监督 药物监督
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 人类乳头瘤病毒 (HPV) 疫苗接种对于预防宫癌至关重要.
- 关于HPV疫苗接种后潜在的甲状腺相关不良事件 (AE) 的新兴担忧存在.
研究的目的:
- 调查HPV疫苗接种与甲状腺疾病之间的潜在关联.
- 分析与甲状腺有关的信号的自发不良事件报告.
主要方法:
- 利用了美国的. 疫苗不良事件报告系统 (VAERS) 数据截至2024年12月31日.
- 进行了不成比例性分析 (PRR,ROR,BCPNN,MGPS) 和子组分析 (性别,年龄,疫苗类型).
- 采用韦布尔模型来评估报告的AE的时间风险模式.
主要成果:
- 在60,840份HPV疫苗报告中确定了13个与甲状腺相关的副作用,其中有积极信号.
- 甲状腺功能低下症 (ROR = 11.65) 和自身免疫性甲状腺炎 (ROR = 4.26) 显示出最强的关联.
- HPV-4疫苗与72.8%的甲状腺副作用有关,主要发生在65岁以下的女性中,报告率在180天内达到顶峰.
结论:
- 表明HPV疫苗接种与甲状腺疾病之间存在潜在联系,特别是甲状腺功能低下和自身免疫性甲状腺炎.
- 强调需要持续的药物监测,以监测疫苗的安全性.
- 建议进一步进行机制研究,以阐明HPV疫苗接种与甲状腺功能障碍之间的关系.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
The Thyroid Gland
6.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.6K
Pharmacovigilance
1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K


