两名幼儿的意外大麻中毒:临床表现和毒动力学 - 一个案例系列
Alessia Cafaro1, Federica Pigliasco1, Sebastiano Barco1
1Biochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Frontiers in pharmacology
|November 27, 2025
概括
儿童意外摄入大麻需要监测delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 的水平. 毒动学概况显示THC的排泄量是可变的,这凸显了儿童药物水平监测的必要性.
科学领域:
- 儿科毒理学 儿科毒理学
- 药理动力学 药理动力学
- 大麻素研究 研究 大麻素研究
背景情况:
- 儿童意外接触食用大麻产品是一个日益严重的公共卫生问题.
- 非特定的临床症状可能会延迟儿童大麻中毒的诊断和治疗.
- 准确的诊断和管理需要毒理学查.
研究的目的:
- 在小儿无意吸食大麻的病例中,描述delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 的毒动学 (TK) 概况.
- 评估随着时间的推移对THC和CBD等离子体度的监测对治疗儿童大麻中毒的有用性.
主要方法:
- 在两名儿科患者 (12和15个月大龄) 经过意外食用大麻后报告的THC和CBD的TK概况.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 测量了血度.
- 进行非分区分析 (NCA) 来计算TK参数,如消除速率常数 (kel) 和半衰期 (t1⁄2).
主要成果:
- 在所有血样本中都始终检测到THC,峰值度为45.0微克/升和54.7微克/升.
- 在一个案例中没有检测到CBD,而在另一个案例中仅暂时检测到CBD (1.11μg/L).
- 计算的THC半衰期为52.5小时和21.7小时,表明显著的变化.
结论:
- 儿童吸食大麻时的THC毒动力学是可变和不可预测的.
- 持续监测THC和CBD血水平对于有效管理儿童中毒至关重要.
- 这些发现强调了疑似儿童大麻暴露的快速毒理学评估的重要性.
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