多组学揭示,NOTCH1促进子宫癌的进展,并减少辐射敏感性
Aihua Guo1, Zhixiong Su2, Enhuan Zhang3
1Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Frontiers in immunology
|November 27, 2025
概括
NOTCH1促进子宫癌的进展,并降低了放射治疗的敏感性. has-miR-449a抑制NOTCH1,为宫癌治疗提供了潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 宫癌是全球女性的主要恶性瘤.
- NOTCH1是NOTCH通路中的一个关键受体,在宫癌中被上调.
- 对于NOTCH1在宫癌进展和治疗耐药性的确切作用尚不完全理解.
研究的目的:
- 研究NOTCH1在宫癌中的多方面的作用.
- 阐明NOTCH1对瘤进展,细胞循环调节和瘤微环境的影响.
- 探索NOTCH1对放射治疗耐药性的影响,并确定潜在的治疗调节器.
主要方法:
- 多omics分析包括单细胞测序和cDNA微阵列.
- 宫癌的体外和体内实验模型.
- 免疫组织化学,细胞循环测定和细胞通信分析.
主要成果:
- NOTCH1的表达与患者的生存有负相关性,并通过推进G1-S阶段过渡来促进宫癌细胞的增殖.
- 高NOTCH1表达与通过MIF途径减少的血细胞透和受损的血细胞分化有关.
- NOTCH1 降低了宫癌细胞的辐射敏感性,而 has-miR-449a 抑制了 NOTCH1,增强了辐射敏感性.
结论:
- NOTCH1驱动子宫癌的进展,并赋予放射电阻.
- has-miR-449a作为NOTCH1的负调节剂,抑制瘤生长并改善放射治疗结果.
- 针对由has-miR-449a调节的NOTCH1通路,为增强宫癌放射治疗提供了一个有前途的策略.
相关概念视频
03:14Notch Signaling Pathway
6.4K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.4K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.4K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.4K
03:03mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
02:55The Nucleolus
10.2K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.2K
01:41Non-Canonical Wnt Signaling Pathways
8.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.2K