黑人和白人美国人中高级糖化终产品和糖尿病的可溶性受体:REGARDS研究
Brittney J Palermo1, Katherine S Wilkinson1, Timothy B Plante1
1Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT 05458.
Obesity medicine
|November 27, 2025
概括
高度糖化终产品 (sRAGE) 的低溶性受体与黑人和白人成年人糖尿病风险更高有关. 然而,sRAGE并没有解释糖尿病发病率中的种族差距.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物化学 生化学
背景情况:
- 糖尿病是美国的一个重大公共卫生问题,与白人成年人相比,黑人成年人受到的影响不成比例.
- 先进糖化终产品 (sRAGE) 的可溶性受体在炎症和糖尿病的发病过程中起作用.
- 了解导致糖尿病差异的因素对于有针对性的干预至关重要.
研究的目的:
- 调查高级糖化终产品 (sRAGE) 溶解受体水平与发生糖尿病风险之间的关联.
- 为了确定sRAGE是否调解了黑人和白人成年人之间糖尿病发病率的观察到的种族差异.
主要方法:
- 从中风的地理和种族差异的原因研究中分析了一个子队列 (4,400名参与者).
- 使用调查加权回归分析,包括修改的波桑回归来估计相对风险.
- 反向赔率加权调度分析评估了sRAGE在种族差异中的作用.
主要成果:
- 在9年半的时间里,糖尿病发生在10%的白人和18%的黑人参与者中.
- 低四分位数的sRAGE显示糖尿病的相对风险较高,尽管在同变量调整后,这种趋势变得无意义.
- sRAGE并没有调解糖尿病发病率的种族差异.
结论:
- 低sRAGE水平与黑人和白人美国人的糖尿病风险增加有关,但随着对其他风险因素的调整,这种关联显著减弱.
- 虽然sRAGE可能表明糖尿病风险,但其临床实用性是有限的,原因是小的,不显著的关联和缺乏种族差异的调解.
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