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Updated: Jun 30, 2026

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在诊断和地细胞淋巴瘤复发时进行突变和拷贝数分析

Erel Joffe1, Manik Uppal2, Serena Zheng3

  • 1Memorial Sloan Kettering Cancer Center, Department of Medicine, New York NY. erelj@tlvmc.gov.il.

Haematologica
|November 27, 2025
PubMed
概括

膜细胞淋巴瘤 (MCL) 复发是由先前存在的克隆驱动的,而不是新的突变. 在诊断时早期检测耐药恶性细胞对于改善长期结果至关重要MCL患者.

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...