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Updated: Jan 10, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
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FVIII轻链变体的不同处理:分泌潜力与蛋白质相对保留

Heike Singer1, Payal Chawla1, Katrin J Czogalla-Nitsche1

  • 1Institute of Experimental Haematology and Transfusion Medicine, University of Bonn.

Haematologica
|November 27, 2025
PubMed
概括

血友性A (HA) 轻链变体中的无意义突变通过影响FVIII蛋白质处理和免疫性而导致抑制剂风险增加. 来自患者的干细胞显示出不同的降解途径,影响抗体形成.

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