带有核心外架构的入银的半孔生物活性玻璃纳米粒子:增强了体外生物活性,抗菌效率和生物相容性
Peerapat Thongnuek1, Woranop Sukparangsi2, Juntratip Jomrit3
1Biomedical Materials and Devices for Revolutionary Integrative Systems Engineering Research Unit (BMD-RISE), Biomedical Engineering Program, Biomedical Engineering Research Center, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
Journal of biomedical materials research. Part A
|November 27, 2025
概括
研究人员设计了具有核心外结构的新型生物活性玻璃纳米粒子 (BGNs). 这些先进的BGN有效地释放离子来对抗感染,并在骨科应用中促进骨愈合.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 再生医学是一种再生医学.
背景情况:
- 骨科生物材料面临着双重挑战:预防感染和促进骨再生.
- 生物活性玻璃纳米粒子 (BGNs) 具有潜力,但需要精确控制离子释放以获得最佳性能.
- 调整银离子 (Ag+) 和离子 (Ca2+) 的释放对于平衡抗菌和骨质生成性质至关重要.
研究的目的:
- 用量身定制的纳米架构设计和合成新的BGN.
- 为了分离和控制Ag+和Ca2+离子的释放.
- 评估工程BGN的抗菌性,骨质生成性和生物相容性概况.
主要方法:
- 使用修改的sol-gel路径合成四种BGN类型,包括固体球体和核心半孔结构.
- 在合成和浸过程中引入银,用于核心外架构.
- 使用电子显微镜,X射线衍射,能量散射X射线光谱,布鲁纳乌-埃梅特-泰勒分析和感应合等离子体质谱法进行了表征.
- 在实验室中评估矿化,对黄金葡萄球菌和大肠杆菌的抗菌活性,以及人类介质干细胞的反应.
- 在卵子中的生物相容性测试使用蛋测试在胆氨酸膜 (HET-CAM).
主要成果:
- 与固体球体 (≈17 m2/g) 相比,半孔BGN的表面积明显更大 (≈860 m2/g).
- 核心外架构在低度下在21天内促进了持续的Ag+和Ca2+释放.
- Ag-doped 介质性 BGN 显示出强大的抗菌活性,并增强了骨矿化.
- 这些BGN支持人类介质干细胞的活力和骨质分化.
- 在HET-CAM测定中没有观察到血管刺激,表明良好的生物相容性.
结论:
- 纳米结构工程,特别是将中等度和核心架构结合起来,优化了BGNs的离子释放.
- 这种方法成功地平衡了抗菌功效与骨质原生支持的骨科应用.
- 开发的多功能纳米玻璃对再生和抗菌疗法具有重大前景.
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