检查点抑制剂诱导的内分泌疾病的不断变化的管理:来自CIITED小组的见解
Priyanka C Iyer1, Nupur Kikani1, Sonya Khan1
1Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Expert review of endocrinology & metabolism
|November 27, 2025
概括
免疫检查点抑制剂 (ICI) 诱导的内分泌异常是癌症治疗的常见副作用. 管理正在发展,正在研究这些疾病的长期影响和潜在的新疗法.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 广泛用于癌症治疗.
- 由ICI引起的内分泌异常是常见的与免疫相关的不良事件.
- 目前存在管理指南,但该领域正在迅速发展.
研究的目的:
- 审查目前对ICI诱导的内分泌病变的理解.
- 突出需要进一步研究的领域,包括糖尿病和骨健康.
- 提出成立一个工作组 (CIITED) 来应对这些挑战.
主要方法:
- 关于ICI和内分泌病的综合文献搜索.
- 纳入作者专家意见.
- 确定未解答的问题和未来的研究方向.
主要成果:
- 虽然对于管理一些ICI内分泌病症存在共识,但许多方面仍然未知.
- 诸如上腺功能衰竭,甲状腺功能低下和糖尿病等疾病往往需要终身激素替代治疗.
- 在这些内分泌毒性管理期间,ICI通常可以安全地继续进行.
结论:
- 由ICI引起的内分泌异常需要持续的研究和不断发展的管理策略.
- 对长期后果和新型治疗方法的进一步调查至关重要.
- CIITED工作组的目标是促进对这些复杂疾病的理解和照顾.
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