Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.2K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.2K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.3K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Digital light processing bioprinting: bioink innovations and applications in tissue and organ regeneration.

Journal of biological engineering·2026
Same author

Development and in vitro evaluation of glycyrrhetinic acid and alpha-lipoic acid co-loaded nanophytosomes: a strategy to mitigate cisplatin-induced hepatocellular damage.

Scientific reports·2026
Same author

Rapamycin and nicotinamide treatment attenuates senescence-associated features in mesenchymal stromal cells isolated from elderly donors by modulating autophagy.

Scientific reports·2026
Same author

Retraction notice to "Dithiothreitol supplementation mitigates hepatic and renal injury in bile duct ligated mice: Potential application in the treatment of cholestasis-associated complications" [Biomedicine & Pharmacotherapy 99 (2018) 1022-1032].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Chlorella vulgaris and Lactobacillus casei Combination Therapy Attenuates Testicular Endoplasmic Reticulum Stress and Dysfunction in a C57BL/6 Mouse Model of NAFLD.

Probiotics and antimicrobial proteins·2026
Same author

CRISPR/Cas9-mediated knockout of TopBP1 shifts the Bax/Bcl-2 balance toward apoptosis in MCF7 breast cancer cells.

Molecular biology reports·2026

相关实验视频

Updated: Jan 10, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

4.0K

转录组网络分析揭示了与酒精相关的细胞衰老和免疫信号通路的调节.

Seyedeh Shima Moosavi1, Ayeh Bolouki2, Negar Azarpira3

  • 1Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.

Journal of studies on alcohol and drugs
|November 27, 2025
PubMed
概括

酒精使用障碍会改变基因表达,影响细胞周期和衰老途径. 这项研究揭示了与酒精相关疾病相关的关键遗传变化,为疾病进展提供了新的见解.

关键词:
酒精使用障碍 (AUD)细胞衰老 细胞衰老网络分析 网络分析翻译学 翻译学 翻译学 翻译学权重基因共同表达网络分析 (WGCNA)

更多相关视频

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.5K
Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

726

相关实验视频

Last Updated: Jan 10, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

4.0K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.5K
Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

726

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 神经科学是一个神经科学.

背景情况:

  • 长期饮酒会破坏免疫功能,提高血压,并导致神经毒性.
  • 酒精使用障碍 (AUD) 显著改变大脑神经化学,增加对癌症和感染的易感性.
  • 了解AUD的分子基础对于解决其全球健康影响至关重要.

研究的目的:

  • 研究酒精使用障碍进展期间基因表达和通路的动态变化.
  • 识别受酒精消费影响的关键基因和分子通路.
  • 为AUD.的遗传基础提供一个新的视角.

主要方法:

  • 利用来自GEO数据库的微阵列数据进行全面的基因表达分析.
  • 进行了功能丰富分析和加权基因共同表达网络分析,以确定关键的基因模块.
  • 在受调节的模块内识别了枢纽基因,以确定关键的分子参与者.

主要成果:

  • 酒精消费显著影响广泛的基因表达.
  • 关键的生物过程和信号通路,包括细胞循环和细胞衰老,显著改变.
  • 受影响的途径包括多基化,NF-κB,FOXO,mTOR,P53,和PPAR信号传递.

结论:

  • 酒精消费和相关疾病可能会改变参与细胞衰老的基因表达.
  • 这些发现突出了酒精影响细胞健康和衰老的分子机制.
  • 对这些途径的进一步研究可以为AUD的治疗策略提供信息.