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在垂体神经内分泌瘤患者的亚临床心肌功能障碍:2D斑点跟踪回声心脏成像研究

Yinxia Li¹, Yifei Yu², Yanxin Xu³

¹Department of Ultrasound, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Endocrine connections

|November 27, 2025

概括

下垂体神经内分泌瘤 (PitNET) 患者通常具有亚临床心脏功能障碍. 二维斑点跟踪回声心脏图显示,左心室全球纵向应变受到BMI,射出分数和性别的影响,IGF-1预测了壮症的问题.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
医疗成像医学成像

背景情况:

下垂体神经内分泌瘤 (PitNETs) 可能导致荷尔蒙失衡,导致心血管问题.
亚临床心脏功能障碍是PitNET患者的潜在并发症.
早期发现心脏功能障碍对于管理与PitNET相关的并发症至关重要.

研究的目的:

在PitNET患者中调查影响左心室全球纵向应变 (GLS) 的因素.
评估二维斑点跟踪心声学 (2D-STE) 在检测亚临床心肌功能障碍方面的实用性.
为了确定GLS受损的预测因素,包括人口,临床和荷尔蒙因素.

主要方法:

对198名住院的PitNET患者进行了回顾性分析.
使用2D斑点跟踪回声心电图 (2D-STE) 来测量左心室全球纵向应变 (GLS).
采用多重线性回归和子组分析来确定GLS的预测因素.

主要成果:

GLS与射出分数 (EF) 和E/e'比率正相关,与BMI负相关.
性别和运营商显著影响了GLS.
在壮症患者中,疾病活性 (IGF-1) 是GLS受损的独立预测因子.

结论:

2D-STE是一种敏感的方法,用于检测PitNET患者的亚临床心肌功能障碍.
GLS受BMI,EF,左心室尺寸和性别的影响.
根据疾病特异性心脏风险分层,考虑诸如IGF-1在壮病中的因素是有价值的.

关键词:

2D-STE可以使用.坑洞网络 (PitNET) 是一个超声心电图 (Echocardiography) 是一种心声回声仪.左心室的全球纵向应变.心肌损伤是指心肌损伤.

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