在女性中,情感性疾病在更年期前,更年期前和更年期后的阶段发作
Alexia Koukopoulos1,2, Leonardo Tondo1,3,4, Gabriele Sani1,5
1Lucio Bini Mood Disorders Centers, Cagliari and Rome, Italy.
Nordic journal of psychiatry
|November 27, 2025
概括
绝经前期出现情绪和焦虑障碍与与绝经前后相比,疾病持续时间和风险增加有关. 绝经后可能涉及较少的情感发病率.
科学领域:
- 生殖精神病学是一种精神病学.
- 情绪和焦虑障碍 情绪和焦虑障碍
- 绝经研究 绝经研究
背景情况:
- 生殖周期阶段与精神症状有关,但更年期过渡期间情绪和焦虑障碍的细节需要澄清.
- 这项研究调查了女性的情绪和焦虑障碍的发病时间和发病率,跨越更年期前,更年期前和更年期后的阶段.
研究的目的:
- 评估女性在更年期前,更年期前和更年期后阶段情绪和焦虑障碍的发病时间和发病率.
- 澄清更年期阶段与抑郁症,双相情绪和焦虑症严重程度之间的关联.
主要方法:
- 一项对928名女性进行的自然主义研究,这些女性首次被诊断为I或II型双相情感障碍 (BD),主要抑郁障碍 (MDD) 或焦虑障碍.
- 绝经后的临床评估,以确定在绝经前,期间或之后的阶段发生情感疾病的发生.
- 心理测量尺度用于情感疾病评估和多变量回归建模,以比较更年期阶段.
主要成果:
- 根据更年期发病阶段,观察到描述性和临床措施的显著差异.
- 绝经前开始的女性经历了更长的疾病持续时间 (1.33x绝经前,1.46x绝经后) 和更高的疾病发作/年.
- 与其他阶段相比,经更年期开始与自杀风险增加有关.
结论:
- 在更年期期间出现情感疾病可能与严重抑郁症和双相情感障碍的过度发病率有关.
- 绝经后的阶段似乎与降低的情感发病率有关.
- 研究结果支持这样一个观点,即更年期的过渡会显著影响情绪和焦虑障碍的发展轨迹.
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