孕产妇的肌肉中毒醇摄入量和子女的先天性心脏缺陷:一个基于人口的病例对照研究
Ruiqi Cen1, L Joseph Su2, Jun Ying3
1Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
BJOG : an international journal of obstetrics and gynaecology
|November 27, 2025
概括
孕妇在怀孕早期服用myo-inositol补充剂可能会降低婴儿先天性心脏缺陷 (CHD) 的风险. 从饮食和补充剂中摄入较高的总myo-inositol与特定心血管疾病的几率较低有关.
科学领域:
- 生殖健康 生殖健康
- 儿童心脏病学 儿童心脏病学
- 营养流行病学 营养流行病学
背景情况:
- 先天性心脏缺陷 (CHD) 是儿科健康的一个重大问题.
- 伊诺西托是天然存在的化合物,存在于食品和补充剂中.
- 孕期营养状况在胎儿发育中起着至关重要的作用.
研究的目的:
- 为了检查母亲在受孕前后摄入的肌肉内醇与后代患心血管疾病的可能性之间的关系.
- 评估与特定类型的CHD的关联,包括隔膜缺陷和流出管道缺陷.
主要方法:
- 基于人口的病例控制研究,利用美国国家出生缺陷预防研究 (NBDPS) 数据库.
- 包括超过11000例患有心血管疾病的病例和11000例没有重大出生缺陷的对照病例.
- 通过食物频率问卷和调查评估myo-inositol摄入量,使用后勤回归模型进行分析.
主要成果:
- 母亲使用myo-inositol补充剂与选择性心脏病总体 (aOR=0.79) 和隔膜缺陷 (aOR=0.61) 的几率降低有关.
- 较高的总myo-inositol摄入量 (≥500 mg/天) 与CHD的概率降低相关,作为一个群体 (aOR=0.88) 和特定类型,如干缺陷 (aOR=0.87).
结论:
- 在孕期期间,母亲摄入的myo-inositol与后代选择先天性心脏缺陷的风险有相反的关联.
- 这些发现表明myo-inositol在预防某些冠状动脉疾病方面具有潜在的保护作用.
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