解读分布,结构-功能-减氧潜力关系以及真菌乳酸酶的最新进展:一种系统的方法
Rhydum Sharma1, Richa Salwan2, Nirlap Kour1,3
1University Centre for Research and Development, Block 4B, Chandigarh University, Mohali, Punjab, 140413, India.
Bioprocess and biosystems engineering
|November 27, 2025
概括
本综述详细介绍了真菌乳酶,具有工业潜力的多铜氧化酶. 它涵盖了它们的基因组学,结构,功能,工程以及人工智能在优化这些酶用于生物催化物的作用.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 酶学 是一种酶学.
背景情况:
- 乳酸酶是具有多种生态作用和工业应用的多铜氧化酶.
- 由于其高氧化还原潜力和素降解能力,真菌乳酸酶,特别是来自阿斯科米科塔和巴西迪奥米科塔,具有显著的兴趣.
研究的目的:
- 进行真菌乳酶的系统分析,涵盖它们的基因组分布,遗传学关系和结构组织.
- 调查真菌乳酶的催化机制,结构功能相关性和翻译后修饰.
- 审查最近的laccase工程的进步和人工智能 (AI) 和机器学习 (ML) 在酶优化中的应用.
主要方法:
- 使用Web of Science,Scopus,PubMed和ScienceDirect进行系统的文献审查.
- 对基因组分布,遗传学归属以及基因结构组织的分析.
- 探索催化机制,结构活动关系和翻译后修改.
主要成果:
- 详细调查真菌laccases的基因组和遗传学方面.
- 探索酶结构-功能相关性,包括氧化还原潜力和糖化作用的影响.
- 概述先进的工程策略和AI/ML在laccase开发中的新兴作用.
结论:
- 由于其独特的特性和易受工程设计的影响,真菌乳酸对工业生物催化有很大的潜力.
- 人工智能和机器学习为理解和增强乳糖酶性能提供了强大的工具,为定制的酶解决方案铺平了道路.
- 对真菌乳酸酶结构,功能和工程的持续研究对于释放它们的全部工业潜力至关重要.
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