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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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功能连接性变化与多发性硬化症中残疾进展有关:一项纵向fMRI研究

Claudia Piervincenzi1, Abhineet Ojha2, Silvia Tommasin2,3

  • 1Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. claudia.piervincenzi@uniroma1.it.

Journal of neurology
|November 27, 2025
PubMed
概括

低残疾多发性硬化症 (PwMS) 患者的休息状态功能连接 (FC) 增加建议补偿. 相比之下,更残疾的PwMS中FC的变化表明了不适应性反应,突出了FC作为多发性硬化症进展的潜在生物标志物.

关键词:
磁共振成像 (MRI) 是一种磁共振成像.多发性硬化症 (MS) 是一种疾病.休息状态的功能性MRI (fMRI)

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科学领域:

  • 神经成像是一种神经成像.
  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物

背景情况:

  • 多发性硬化症 (PwMS) 患者的静止状态功能连接 (FC) 的变化可能代表适应性或不适应性可塑性.
  • 纵向调查FC演变及其与残疾进展的关系对于理解这些变化至关重要.

研究的目的:

  • 检查多发性硬化症 (PwMS) 患者休息状态功能连接 (FC) 的5年变化.
  • 评估这些FC变化与残疾进展有关的临床相关性.

主要方法:

  • 包括156名PwMS和156名健康受试者 (HS) 进行3T-MRI扫描,间隔4-6年.
  • 评估了临床和神经心理学措施,包括EDSS,9HPT,T25FWT,PASAT3和SDMT.
  • 分析休息状态网络 (RSN) 使用独立组件分析和与临床结果相关联的FC变化.

主要成果:

  • 与HS相比,低残疾PwMS在所有RSN中显示出更高的基线FC,与更好的基线表现和更少的随访恶化相关.
  • 轻度和高度残疾组表现出混合的FC异常;轻度残疾组的更高的FC与更差的基线得分和更大的临床恶化有关.
  • 从长度上看,低残疾PwMS显示FC增加与更好的结果相关,而其他组显示FC减少与临床恶化相关.

结论:

  • 低残疾PwMS的FC增加可能反映了补偿机制.
  • 在更具残疾的PwMS中,FC变化可能代表了适应不良的反应.
  • 静止状态FC显示出作为监测多发性硬化症进展和治疗反应的生物标志物的潜力.