与代谢功能障碍相关的脂肪性肝病和不良怀孕结果:全国性的队列研究
Young Mi Jung1,2, Taesu Kim3, Min-Jeong Oh1
1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Hepatology international
|November 27, 2025
概括
脂肪性肝病 (SLD) 亚型,包括MASLD,MetALD和ALD,显著增加了不良妊娠结果. 由于心脏代谢风险因素增加了风险,突出显示了患病妇女需要加强产前护理的必要性.
科学领域:
- 肝病学和胃肠道学
- 产科和妇科 产科和妇科
- 公共卫生和流行病学
背景情况:
- 最近的国际共识为脂肪性肝病 (SLD) 建立了新的命名体系.
- 了解这些更新的SLD分类对怀孕的影响对于母亲和婴儿健康至关重要.
- 现有研究可能无法充分反映与新定义的SLD亚型相关的风险.
研究的目的:
- 使用修订后的命名法,评估肥胖性肝病 (SLD) 亚型与不良妊娠结果之间的关联.
- 评估代谢功能障碍相关的脂肪性肝病 (MASLD),代谢功能障碍和与酒精有关的肝病 (MetALD) 以及与酒精有关的肝病 (ALD) 对妊娠并发症的影响.
- 为了确定心脏代谢风险因素是否会改变SLD和apos之间的关系.
主要方法:
- 全国范围内,基于人口的研究分析了290,527名分娩单独婴儿的妇女.
- 参与者被分为非SLD,MASLD,MetALD和ALD组,根据怀孕前一年内进行的健康检查.
- 使用调整的赔率比率 (aOR) 进行统计分析,以评估各种 apos 的风险.
主要成果:
- 与非SLD相比,MASLD,MetALD和ALD独立地与明显更高的pos风险相关 (aORs从2.28到2.45不等).
- 这些SLD亚型增加了妊娠糖尿病 (GDM),妊娠高血压障碍 (HDP) 和早产的风险.
- 无论是MASLD还是ALD,但不是MetALD,都与低出生体重风险的增加有关;心脏代谢风险因素的增加进一步放大了后风险.
结论:
- MASLD,MetALD和ALD是妊娠不良结果的重要独立风险因素.
- 多种心脏代谢风险因素的存在加剧了女性患SLD后的风险.
- 加强产前管理对于患有SLD的孕妇至关重要,特别是那些患有多种心脏代谢风险因素的孕妇,以减轻妊娠并发症.
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