肝硬化/纤维化相关的生物标志物在患有与代谢功能障碍相关的肝硬化病的患者
Zhi Peng1, Zijin Wang1, Juan Wang1
1Department of Gastroenterology, The First Affiliated Hospital of Jishou University, Jishou, China.
Biomarkers in medicine
|November 27, 2025
概括
在代谢功能障碍相关的脂肪性肝病 (MASLD) 中,较高的低密度脂蛋白 (LDL) 水平与肝脏脂肪症和纤维化严重程度的增加相关. 随着肝纤维化病的进展,甘油三 (TG) 水平下降.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 生物标志物发现发现
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 了解肝硬化和纤维化生物标志物对于患者管理至关重要.
研究的目的:
- 在被诊断为MASLD的患者中,研究与肝硬化和纤维化相关的生物标志物.
- 为了探索脂质样本和MASLD患者肝脏疾病的严重程度之间的关系.
主要方法:
- 158名患有MASLD的患者接受了Fibroscan,以评估肝硬化症 (CAP值) 和肝纤维化 (E值).
- 患者根据肥胖症的严重程度 (轻度,中度,严重) 和纤维化阶段 (没有,早期,晚期/肝硬化) 将患者分为几组.
- 在脂质样本 (TG,CHOL,LDL) 和肝病严重程度标志物之间进行了相关性分析.
主要成果:
- 肝硬度 (E值) 与胆固醇 (CHOL) 和低密度脂蛋白 (LDL) 有负相关性.
- 肝肥胖症 (CAP值) 与LDL水平正相关.
- 严重脂肪肝患者的TG,CHOL和LDL明显高于轻度肝炎患者. 中度脂肪肝也显示TG和LDL的升高.
- 与晚期纤维化和肝硬化组相比,早期纤维化组的甘油三 (TG) 含量更高.
结论:
- 超脂血症加剧肝硬化症,而TG水平随着肝纤维化的进展而降低.
- 脂质新陈代谢受损,随着肥胖症的严重程度的增加.
- 在MASLD中,LDL是与肝硬化症和纤维化症的严重程度相关的重要指标.
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