基于人群的队列中的多发病和无性皮肤炎:严重程度依赖的关联与明显的非无性多发病模式
Leon A Miltner1, Laura Loman1, Josué Almansa Ortiz2
1Department of Dermatology, University Medical Center Groningen, Groningen, The Netherlands.
患有亚形性皮肤炎 (AD) 的人患有非亚形性多病症的可能性要高得多,特别是那些患有中度至重度疾病的人. 在阿尔茨海默病患者中观察到涉及口腔面部和心脏代谢条件的独特多病态模式.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 亚托皮炎 (AD) 越来越多地被认为是一种全身性疾病.
- 系统性炎症是阿尔茨海默病的关键特征,将其与各种并发症联系起来.
- 了解AD和多病症之间的关联对于全面的患者护理至关重要.
研究的目的:
- 为了研究亚托邦性皮肤炎 (AD) 和非亚托邦性多病症之间的关系.
- 在患有和没有AD的个体中识别不同的多病态模式.
- 分析阿尔茨海默氏症严重程度对多重疾病患病率的影响.
主要方法:
- 一项基于人口的队列研究,涉及来自北荷兰的37,193名参与者.
- 用问卷,药物记录和临床评估评估了15个领域的52种疾病的终身患病率.
- 多发病症被定义为至少两种疾病,非形多发病症不包括特定的形疾病. 使用了后勤回归和潜在类分析.
主要成果:
- 8.7%的参与者患有阿尔茨海默病,与没有阿尔茨海默病的人相比,非阿托皮多发病率 (OR 1.47) 的几率更高.
- 中度至重度的AD与非阿托皮多发病率的增加相关 (中度至重度和轻度的AD的aOR分别为1.74和1.41).
- 确定了五种不同的多病态模式,在阿兹海默症患者中观察到独特的口腔面部和心脏代谢模式.
结论:
- 亚托皮性皮肤炎,特别是中度至重度病例,与非亚托皮多发病率的增加密切相关.
- 独特的多病态模式,包括口腔面部和心脏代谢参与,是阿尔茨海默病患者的特征.
- 跨学科的管理方法对于患有阿尔茨海默症和并发症的患者至关重要.
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