哈尔普指数作为营养,炎症和凝血之间的桥梁,用于预测中风患者的DVT风险
Siqi Zhang1,2, Shuangyang Niu1,2, Yonghui Wang2
1School of Nursing and Rehabilitation, Shandong University, Jinan, China.
Biological research for nursing
|November 27, 2025
概括
血红蛋白 - 专蛋白 - 淋巴细胞 - 血小板 (HALP) 指数预测中风患者的深静脉血栓 (DVT). 较高的HALP得分与较低的DVT风险有关,这表明其在预防DVT方面的价值.
科学领域:
- 生物医学科学 生物医学科学
- 临床医学 临床医学
- 血液学 血液学 血液学
背景情况:
- 血红蛋白-专蛋白-淋巴细胞-血小板 (HALP) 指数整合了营养,炎症和免疫状态.
- 它对中风患者深静脉血栓形成 (DVT) 的预测作用尚未得到充分证实.
- 哈尔普对凝血生物标志物,如D-二聚体的影响需要进一步调查.
研究的目的:
- 研究中风患者的HALP指数和DVT发生之间的关联.
- 探索HALP在调节D-二次元水平和DVT形成方面的潜在作用.
- 评估HALP作为中风患者群体内DVT的预测因素.
主要方法:
- 对611名中风患者的回顾性研究,分为HALP指数四分之一.
- 使用多变量逻辑回归和受限立方线 (RCS) 分析.
- 适度分析检查了HALP和D-二次体水平之间的相互作用.
主要成果:
- 较高的HALP指数四分位数显示出与DVT发生的显著反向关联 (p < .001).
- RCS建模表明了一个值效应,在HALP水平33.5.5以下,DVT风险增加.
- HALP显著缓解了D-二次体和DVT之间的关联,特别是在男性和超重个体中.
结论:
- 哈尔普指数是一个强有力的,独立的预测器,中风后的DVT.
- HALP在D-二聚合物的原血栓性作用中起到缓和作用.
- 哈尔普指数为早期DVT风险分层和中风患者个性化预防提供了临床实用性.
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