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在患有精神分裂症和双相情感障碍的非裔后裔中皮层厚度的改变:一个探索性分析

Rômulo K P Silva¹, Mariélia B L de Freitas², Licia P Luna³

¹Neuropsychiatry Service, Nina Rodrigues Hospital, São Luís, Brazil.

Psychiatry research. Neuroimaging

|November 27, 2025

概括

精神分裂症 (SZ) 和双相情感障碍 (BD) 在代表性不足的人群中不同影响大脑结构. 这项研究揭示了SZ和BD的非裔和土著个体的皮质厚度明显变化.

科学领域:

神经成像是一种神经成像.
精神病学是一个精神病学.
人类解剖学人类解剖学

背景情况:

精神分裂症 (SZ) 和双相情感障碍 (BD) 是复杂的精神疾病.
现有的神经成像研究主要包括欧洲,北美和亚洲的队列.
了解不同人群中大脑结构的变化至关重要.

研究的目的:

调查SZ和BD的非洲裔和土著人皮层厚度 (CT) 的形态变化.
为了比较这些人群中SZ,BD和健康对照 (HC) 之间的结构性大脑差异.
探索临床症状与大脑结构之间的相关性.

主要方法:

利用来自23名SZ患者,20名BD患者和21名HC (22至31岁) 的神经影像数据.
使用FreeSurfer和Desikan-Killiany图谱计算了68个大脑区域的皮层厚度 (CT).
使用ANCOVA进行了统计分析,使用年龄作为共变量和邦费罗尼校正.

主要成果:

与SZ和HC相比,双极性障碍 (BD) 患者在右侧轨道前皮层和左侧轨道上皮层的CT显著减少,与SZ和HC相比.
在一组患者中,抑郁症状与左侧近海马环厚度有负相关性.
躁狂症状与右侧轨道前额CT显示出负相关性.

结论:

在SZ和BD中,结构性大脑变化在不同种族群体之间有所不同.
强调需要在神经成像研究中包括代表性不足的人群.
提供了对不同个体精神疾病的神经解剖学基础的见解.

关键词:

双极性障碍是一种双极性障碍.皮层厚度皮层厚度民族身份民族身份精神分裂症是一种精神分裂症.结构神经成像结构神经成像

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